The Anticancer Benefits of Quercetin: A Comprehensive Review

Researched and written by Keith Bishop, Clinical Nutritionist, Cancer Coach, Retired Pharmacist

Quercetin, a naturally occurring flavonoid in many fruits and vegetables, has garnered significant attention for its anticancer properties.

Mechanisms of Action Against Cancer

Quercetin exerts its anticancer effects through multiple pathways. It inhibits tumor proliferation, invasion, and metastasis by modulating various signaling pathways within cancer cells. These pathways include apoptotic, p53, NF-κB, MAPK, JAK/STAT, PI3K/AKT, and Wnt/β-catenin pathways. Quercetin also regulates the activity of oncogenic and tumor suppressor ncRNAs, contributing to its anticancer properties.

Food Sources of Quercetin

Quercetin is abundant in many fruits and vegetables. Here are the top 10 foods rich in quercetin:[i]

• Onions (especially red onions)
• Apples (especially the peals)
• Berries (such as blackberries, blueberries, and cranberries)
• Kale
• Broccoli
• Spinach
• Capers
• Cherry tomatoes
• Green tea
• Parsley

Including these foods in your diet can help you reap the benefits of quercetin.

Synergistic Cancer Benefits of Quercetin with Other Herbs

Quercetin can work synergistically with other herbs to enhance its anticancer effects. For example, combining quercetin with turmeric (curcumin) has been shown to have a more potent anticancer effect due to their complementary mechanisms. Other herbs like green tea (epigallocatechin gallate) and grape seed extract (proanthocyanidins) also exhibit synergistic effects with quercetin.

Potential Interactions Quercetin with Chemotherapy and Radiation Therapy

While quercetin has promising anticancer properties, it is essential to consider its interactions with conventional cancer treatments. Some studies suggest that quercetin may enhance the efficacy of chemotherapy and radiation therapy by sensitizing cancer cells to these treatments. However, it may interfere with the metabolism of some chemotherapy drugs, increase their blood levels in the body, increase side effects, and increase effectiveness. It is crucial to consult with a healthcare provider familiar with herbal metabolism and treatment interactions before combining quercetin with these therapies to avoid potential adverse effects.

Quercetin Interactions with Anticoagulant Drugs

Like most herbs, quercetin has anticoagulant properties, which can increase the anticoagulant, cause prolonged bleeding, and affect medications. Consult with your healthcare team about appropriateness and how to monitor.

Quercetin Interactions with Surgery

Quercetin has anticoagulant properties, which can increase the risk of bleeding during surgery. Therefore, to minimize this risk, it is typically recommended to stop taking quercetin supplements at least one week before any surgical procedure.

Quercetin Supplements

Studies have shown that quercetin’s poor solubility and metabolism in the body limits its absorption. Quercetin is available in foods at up to about 50mg per serving. Higher dosage levels are available as supplements. Ultrabotanica has developed a patented process to enable the absorption of quercetin into the body. Onco-Adjunct Pathway 2 contains curcumin and quercetin that is readily absorbed in a molecular form, making it available to interact with the cells in your body.

Onco-Adjunct Pathway 2 with quercetin and other supporting supplements are available from the following sources with the discount code: PREVAIL5.

• Ultrabotanica: https://ultrabotanica.com/product-category/onco-adjunct/
  
  
• Flourish Nutraceuticals: https://flourishnutraceuticals.com/product-category/cancer-support/

Quercetin Cancer Conclusion

In conclusion, quercetin shows excellent potential as an anticancer agent due to its ability to modulate various cellular pathways and work synergistically with other herbs. However, it is essential to be aware of its interactions with conventional cancer treatments and surgical procedures. Always consult with a healthcare provider before incorporating quercetin into your cancer treatment regimen.

Reference Sources

[i] https://www.lifeextension.com/wellness/antioxidants/quercetin-foods